List of endpoints that we predict:
QSAR Lab specializes in a computational risk assessment of chemical substances including Physico-chemical , eco-toxicological , and toxicological properties for almost every endpoints e.g:
PHISICO-CHEMICAL PROPERTIES
| REACH | Endpoint | TEST |
|---|---|---|
| 7.2 | Melting/freezing point | OECD 102 |
| 7.3 | Boiling point | OECD 103 |
| 7.4 | Relative density | OECD 109 |
| 7.5 | Vapour pressure | OECD 104 |
| 7.6 | Surface tension | OECD 115 |
| 7.7 | Water solubility | OECD 105 |
| 7.8 | Partition coefficient n-octanol/water | OECD 107, 117, 123 |
| 7.9 | Flash-point | EU A.9 |
| 7.10 | Flammability | EU A.10, EU A.12, EU A.13 |
| 7.11 | Explosive properties | EU A.14 |
| 7.12 | Self-ignition temperature | EU A.15 |
| 7.13 | Oxidising properties | EU A.17 |
| 7.14 | Granulometry | |
| 7.15 | Stability in organic solvents and identity of relevant degradation products | |
| 7.16 | Dissociation constant | OECD 112 |
| 7.17 | Viscosity | OECD 114 |
TOXICITY
| REACH | Endpoint | TEST |
|---|---|---|
| 8.1 | Skin irritation or skin corrosion | OECD 439, 430, 431, 435, EU B.40, EU B.40 bis |
| 8.1.1 | In vivo skin irritation | OECD 439, 430, 431, 435 |
| 8.2 | Eye irritation | EU B.47, OECD 437, EU B.48, OECD 438, OECD 460, OECD 491, OECD 492 |
| 8.2.1 | In vivo eye irritation | OECD 405 |
| 8.3 | Skin sensitisation | OECD 429, 406, 442A, 442B, 442C, 442D, 442E, |
| 8.4 | Mutagenicity | OECD 473 |
| 8.4.1 | In vitro gene mutation study in bacteria | OECD 471 |
| 8.4.2 | In vitro cytogenicity study in mammalian cells or in vitro micronucleus study | OECD 487 |
| 8.4.3 | In vitro gene mutation study in mammalian cells | OECD 490 |
| 8.5 | Acute toxicity | |
| 8.5.1 | By oral route | OECD 420, 423, 425 |
| 8.5.2 | Acute toxicity By inhalation | OECD 403, 433, 436 |
| 8.5.3 | Acute toxicity By dermal route | OECD 402 |
| 8.6 | Repeated dose toxicity | |
| 8.6.1 | Short-term repeated dose toxicity study (28 days), one species, male and female, most appropriate route of administration, having regard to the likely route of human exposure. | OECD 422 |
| 8.6.2 | Sub-chronic toxicity study (90- day), one species, rodent, male and female, most appropriate route of administration, having regard to the likely route of human exposure. | |
| 8.7 | Reproductive toxicity | |
| 8.7.1 | Screening for reproductive/developmental toxicity, one species | OECD 421, 422 |
| 8.7.2 | Pre-natal developmental toxicity study, one species, most appropriate route of administration, having regard to the likely route of human exposure | OECD 414 |
| 8.7.3 | Two-generation reproductive toxicity study, one species, male and female, most appropriate route of administration, having regard to the likely route of human exposure | OECD 416 |
| 8.9.1 | Carcinogenicity study | OECD 451, 453 |
ECOTOXICITY
| REACH | Endpoint | TEST |
|---|---|---|
| 9.1 | Aquatic toxicity | |
| 9.1.1 | Short-term toxicity testing on invertebrates (preferred species Daphnia) | OECD 202 |
| 9.1.2 | Growth inhibition study aquatic plants (algae preferred) | OECD 201, 221 |
| 9.1.3 | Short-term toxicity testing on fish: the registrant may consider long-term toxicity testing instead of short- term. | OECD 203, OECD 236, OECD 210 |
| 9.1.4 | Activated sludge respiration inhibition testing | OECD 209 |
| 9.1.5 | Long-term toxicity testing on invertebrates (preferred species Daphnia) | OECD Guideline 211/ EU Method C.20 |
| 9.1.6 | Long-term toxicity testing on fish | |
| 9.1.6.1 | Fish early-life stage (FELS) toxicity test | OECD TG 210 |
| 9.1.6.2 | Fish short-term toxicity test on embryo and sac-fry stages | OECD 212 |
| 9.1.6.3 | Fish, juvenile growth test | OECD 215 |
| 9.2.1 | Degradation (biotic) | |
| 9.2.1.1 | Ready biodegradability | OECD 301 |
| 9.2.1.2 | Simulation testing on ultimate degradation in surface water | OECD 309 |
| 9.2.1.3 | Soil simulation testing | OECD 307 |
| 9.2.1.4 | Sediment simulation testing | OECD 308 |
| 9.2.2.1 | Hydrolysis as a function of pH | OECD 111 |
| 9.2.3 | Identification of degradation products | |
| 9.3.1 | Adsorption/desorption screening | OECD 106, OECD 121 |
| 9.3.2 | Bioaccumulation in aquatic species, preferably fish | OECD 305 |
| 9.4 | Effects on terrestrial organisms | |
| 9.4.1 | Short-term toxicity to invertebrates | OECD 214 |
| 9.4.2 | Effects on soil micro-organisms | |
| 9.4.3 | Short-term toxicity to plants | |
| 9.4.4 | Long-term toxicity testing on invertebrates | |
| 9.4.6 | Long-term toxicity testing on plants | |
| 9.5.1 | Long-term toxicity to sediment organisms | |
| 9.6.1 | Long-term or reproductive toxicity to birds |
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